Preparation and Characterization of a New Alternative Formulation of Sodium p-aminosalicylate

HERGERT L.; SPERANDEO N.; ALLEMANDI D.; MAZZIERI M.

American Pharmacist Association

Año: 2011 vol. 15 p. 101 - 101

odium p-aminosalicylate is an orphan drug used in patients affected with multidrug-resistant tuberculosis. In this article, the preparation and characterization of a new alternative formulation of p-aminosalicylate is described. It consists of a powder for extemporaneous reconstitution, p-aminosaliyilate–extemporaneous, to be orally administered in solution. It is finally packaged in a tightly closed, light-resistant glass container as a unitary dose. In order to promote accessibility to multidrug-resistant tuberculosis treatment, the formulation is low cost and simple to manufacture, being compounded with only four ingredients. To improve patient compliance and treatment adherence, the unpleasant taste of p-aminosalicylate was masked as p-aminosalicylate–extemporaneous, which is easier to drink. The p-aminosalicylate–extemporaneous was characterized in relation to its content uniformity, time of blending, powder bulk properties (flowability), and stability. The proposed alternative f