A linear free energy relationship treatment of the affinity between carboxymethylcellulose and basic drugs

M. V. RAMIREZ RIGO, D. A. ALLEMANDI AND R. H. MANZO

MOLECULAR PHARMACEUTICS

American Chemical Society

Año: 2004 vol. 1 p. 383 - 383

1543-8384

p align="left">With the purpose of getting information about the factors that determine the affinity between basic drugs (B) and the acid form of carboxymethylcellulose (HCMC), the constant Kip between basic drugs (B) and the acid form of carboxymethylcellulose (HCMC), the constant Kip for the equilibrium HCMC + B a CMC- BH+ was measured using a set of nine model B. A linear free energy relationship (LFER) was developed through a multiple correlation of log Kip