Design of novel antifungal mucoadhesive films. Part I: Pre-formulation studies

MANUEL LLABOT, JUAN; SANTIAGO PALMA,; RUBEN MANZO,; DANIEL ALBERTO ALLEMANDI

INTERNATIONAL JOURNAL OF PHARMACEUTICS

Elsevier

Año: 2007 vol. 330 p. 54 - 54

0378-5173

p class="MsoTitle" style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: justify">In this work, pre-formulation studies concerning the design of novel mucoadhesive films have been carried out. The rationality of the design is based on the utilization of mucoadhesive polymers (carbomer and carboxymethylcellulose), a plasticizer (polyethyleneglycol 400) and a surfactant (ascorbyl palmitate, ASC16). In their preparation, the casting method using water as a solvent was employed. To provide a better understanding of the structural arrangements produced during the casting process, the changes in morphology (Cryo-TEM) and rheology (viscosity) of the film forming gels were evaluated. When polyethyleneglycol 400 (PEG400) was included as a plasticizer, a disorder was produced in the netwo