Mechanism of Lidocaine Release from Carbomer-Lidocaine Hydrogels

JIMENEZ KAIRUZ, ALVARO; DANIEL ALBERTO ALLEMANDI; RUBEN MANZO,

JOURNAL OF PHARMACEUTICAL SCIENCES

Wiley-Liss, Inc. and the American Pharmaceutical Association

Año: 2002 vol. 91 p. 267 - 267

0022-3549

span lang="en" style="FONT-SIZE: 8pt; COLOR: black; FONT-FAMILY: Arial; mso-bidi-font-size: 10.0pt; mso-fareast-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-ansi-language: EN-US; mso-fareast-language: ES; mso-bidi-language: AR-SA"> Rheology, acid-base behavior, and kinetics of lidocaine release of carbomer-lidocaine (C-L) hydrogels are reported. A series of (C-L)(x) (x = mol% of L = 25, 50, 75, 100) that covers a pH range between 5.33 and 7.96 was used. Concentrations of ion pair ([R-COO(-)LH(+)]) and free species (L) and (LH(+)) were determined by the selective extraction of (L) with cyclohexane (CH) together with pH