Swellable drug-polyelectrolyte matrices (SDPM) of alginic acid. Characterization and delivery properties

RAMIREZ RIGO, VERONICA; DANIEL ALBERTO ALLEMANDI; RUBEN MANZO,

INTERNATIONAL JOURNAL OF PHARMACEUTICS

Elsevier

Año: 2006 vol. 322 p. 36 - 36

0378-5173

p class="MsoTitle" style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: justify">This study deals with the development and characterization of the delivery properties of swellable drug?polyelectrolyte matrices (SDPM) of alginic acid (AA). Complexes (AA?D)x in solid state were obtained by neutralization of AA with different molar proportions (x) of model basic drugs (D), in which D is atenolol, metoclopramide and propranolol. They were characterized by DSC, IR and X-ray diffraction. Matrices prepared by compaction of (AA?D)x alone or in a mixture with sodium alginate (NaAA) were subjected to measurements of solvent up-take, release kinetics and erosion in three media (water, buffer of pH 6.8 and 0.01 M HCl). In addition, the dynamics of swelling was also evaluated. All SDPM