Optimization of skin permeation and distribution of ibuprofen by using nanostructures (coagels) based on alkyl vitamin C derivatives.

VERÓNICA SAINO,; DANIELA MONTI,; BURGALASSI S.,; TAMPUCCI S.; PALMA S. D.; ALLEMANDI D. A.; CHETONI P.

ELSEVIER SCIENCE BV

Año: 2010 vol. 76 p. 443 - 443

font size="1" face="AdvGulliv-R"> In this investigation two vitamin C-based -6-O-ascorbic acid esters (ASC12 and ASC16), able to form liquid?crystal structures (coagels) was evaluated for their potential usefulness to promote the permeation and distribution of ibuprofen (IBU). Two coagel formulations and the same coagels added of polyethylene glycol (PEG-400) were assayed in comparison with a commercial product (Arfen_) by using hairless rat skin as model. The ASC16 and ASC12 derivatives gave rise to stable supramolecular assemblies in water and in water/ PEG mixtures (coagels), allowing the solubilization of IBU (