Interaction between Eudragit® E100 and anionic drugs: Addition of anionic polyelectrolytes and their influence on drug release performance.

QUINTEROS, D. A.; MANZO R. H. ; ALLEMANDI, D. A

JOHN WILEY & SONS INC

Año: 2011 vol. 100 p. 4664 - 4664

p style="MARGIN: 0cm 0cm 0pt; mso-layout-grid-align: none" class="MsoNormal">In this work, we report results concerning the study of solid complexes compounded by a cationic polymethacrylate (EudragitR_ E100, Eu) and mesalazine (M) (Eu?Mx complex). The influence of an anionic polyacrylic acid polymer (carbomer, C) on dissolution behaviour of M from the complex was evaluated (Eu?MxCy complex). The dissolution profiles and solvent front movements of solid matrices in different media (water, buffer pH 7.4, 0.9% NaCl) were investigated and ionic interactions among Eu, M, and C were determined through Fourier transform infrared (FT-IR) spectroscopy. For Eu?Mx complexes, the affinity between M and Eu modulated the delivery of free M in solution, with the dissolution media affecting the delivery rate mainly due to an ionic interchange process between M and anionic electrol