Enhanced dissolution and systemic availability of albendazole formulated as solid dispersions.

CASTRO SILVINA; SANCHEZ BRUNI SERGIO; URBIZU LUCIA; CONFALONIERI ALEJANDRA; CEBALLOS LAURA; LANUSSE CARLOS; ALLEMANDI DANIEL; PALMA SANTIAGO

TAYLOR & FRANCIS INC

Lugar: Londres; Año: 2012 p. 1 - 1

olid dispersions (SDs) containing the anthelmintic compound albendazole (ABZ) and either Pluronic 188 (P 188) or polyethylene glycol 6000 (PEG 6000) as hydrophilic carriers were formulated. Drug?polymers interactions in solid state were investigated using different techniques. Only a 4% of total ABZ was dissolved at 5 min post-incubation, reaching dissolution rates of 32.8% (PEG 6000) and 69.4% (P 188) in SDs. In this way, P 188 was substantially more efficient as ABZ dissolution promoter in comparison to PEG 6000, especially at the initial stages of the dissolution processes (