Development of a modified-release hydrophilic matrix system of a plant extract based on co-spray-dried powders

PIÑA JULIANA; BUCALÁ VERÓNICA; ALLEMANDI DANIEL; GALLO LOREANA; RAMIREZ RIGO VERÓNICA

ELSEVIER SCIENCE SA

Lugar: Amsterdam; Año: 2013 vol. 241 p. 252 - 252

he aim of this paper was to develop a modi fi ed-release solid dosage form containing a plant extract, namely Hamamelis virginiana extract. To this purpose, a co-spray-dried powder consisting of H. virginiana extract, sodium carboxymethylcellulose (Na-CMC) and colloidal silicon dioxide (SiO 2 ) was formulated, which showed good fl ow properties for direct compression and was useful as a modi fi ed-release hydrophilic matrix system. H. virginiana extract was selected as a model plant extract due to its extensive use in treatments for chronic varicose veins. Different ternary co-processed powders were obtained by modifying the viscosity grade and concentration of Na-CMC. For a given set of spray-drying operating conditions, the use of medium viscosity (MV) Na-CMC in the formula led to high process yields and satisfactory product moisture contents. Compacted powders were able to modulate the extract release in different media, being the polymer concentration the fundament