Equilibrium and Release Properties of Aqueous Dispersions of non Steroidal Antiinflammatory Drugs Complexed With Polyelectrolyte Eudragit E 100.

QUITEROS DANIELA; ALLEMANDI DANIEL; MANZO RUBEN

Scientia Pharmaceutica

Österreichische Apotheker-Verlagsgesellschaft

Lugar: Viena; Año: 2012 vol. 80 p. 487 - 487

0036-8709

quilibria and release properties of aqueous systems consisting of a set of five non-steroidal anti-inflammatory drugs (AH) complexed with the cationic polymethacrylate Eudragit E 100 (EU) are reported in this study. The composition (EU(AH)50 (HCl)50) having fifty mole percent of each counterion (A− and Cl−) produces clear, stable aqueous dispersions in which a remarkably high proportion of AH (higher than 98%) is condensed with the PE under the form of ion pairs. This property expands the interval of pH in which AH are aqueous soluble. The set of AH contains members with and without an alpha methyl group (-(CH3)CH-COOH: Flurbiprofen, Naproxen, Ketoprofen) and (-CH2-COOH: Diclofenac, Indomethacin). The proportion of ion pairs in the complexes was lower in the former group. Release of AH from the complexes toward a saline (NaCl 0.9%) solution was assayed in Franz cells. The five complexes behaved as drug carriers that exhibited a slow drug release with a remarkable zero orde