Solid dispersions containing Albendazole: Influence of dissolution media composition on in vitro drug release

NOELIA L. GONZALEZ VIDAL; SILVINA G. CASTRO; SERGIO SANCHEZ BRUNI; DANIEL ALLEMANDI; SANTIAGO PALMA

DISSOLUTION TECHNOLOGIES, INC

Lugar: Hockessin, Delaware (USA); Año: 2014 vol. 21 p. 42 - 42

he rate-limiting step to drug absorption is often dissolution from the dosage form, especially for poorly soluble compounds. Two possibilities for improving the dissolution of these drugs are to increase the available surface area and to improve their apparent solubilities under physiologically relevant conditions with surfactants as wetting agents. Albendazole (ABZ), one of the most effective broad-spectrum antihelminthic agents, has a very low aqueous solubility, which leads to an erratic availability. Solid dispersions (SD) with different amounts of carriers (P188 and PEG6000) were formulated to improve the ABZ dissolution rate. When the dissolution test is used to infer biopharmaceutical properties of the dosage form, it is essential that the method simulates the gastrointestinal conditions. The objective of this study was to examine the applicability of different dissolution media to the evaluation of ABZ and ABZ-SD dissolution rates. Dissolution profiles were performed by th