Drug release from carbomer:carbomer sodium salt matrices with potential use as mucoadhesive drug delivery system

JUAN M. LLABOT, RUBEN H. MANZO, DANIEL A. ALLEMANDI

INTERNATIONAL JOURNAL OF PHARMACEUTICS

Elsevier

Año: 2004 vol. 276 p. 59 - 59

0378-5173

font face="Times New Roman" size="1"> In vitro mucoadhesion, water uptake, and drug release of nystatin (N) from matrices of carbomer (C) and lyophilized carbomer sodium salt (CNaL) mixtures were evaluated. Matrices with different ratios C:CNaL were prepared by direct compression. Commercial C as well as lyophilized powder (CL) were used. In vitro mucoadhesion increased as the proportion of C in the matrix was raised. The same effect was observed when C was replaced by CL. Matrices in which C was replaced by CL