Design of novel antifungal mucoadhesive films. Part II: Formulation and In vitro biopharmaceutical evaluation.

MANUEL LLABOT, JUAN; SANTIAGO PALMA,; RUBEN MANZO,; DANIEL ALBERTO ALLEMANDI

INTERNATIONAL JOURNAL OF PHARMACEUTICS

Elsevier

Lugar: doi:10.1016/j.ijpharm.2006.12.; Año: 2007 p. 1 - 1

0378-5173

p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: justify; mso-layout-grid-align: none">This paper deals with the formulation of the mucoadhesive films containing nystatin. The design and formulation of the films was based on the mucoadhesive properties of carbomer 934P (CB) and carboxymethycellulose (NaCMC), and also on the plasticizer properties of polyethyleneglycol 400 (PEG400). A surfactant (ascorbyl palmitate, ASC16) was added to the system to aid in nystatin dispersion. Addition of these last two components produced a significant improvement in physicalmechanical properties (flexibility and strength) as well as an increase in the nystatin release rate. Xray powder diffraction (XRPD) and scanning electronic microscopy (SEM) were used to evaluate the morphological changes in the films while PEG400 and ASC16 were added to the form