Coagels from 6-O-alkyl Ascorbic Acid Derivatives as drug carriers: Structure and rheology.

SANTIAGO PALMA,; JIMENEZ KAIRUZ, ALVARO; LAURA FRATONI,; LO NOSTRO, PIERANDREA; RUBEN MANZO,; DANIEL ALBERTO ALLEMANDI

IL FARMACO; EDIZIONE PRATICA.

Elsevier

Año: 2003 vol. 22 p. 305 - 305

0014-827X

span lang="en" style="FONT-SIZE: 8pt; COLOR: black; FONT-FAMILY: Arial; mso-bidi-font-size: 10.0pt; mso-fareast-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-ansi-language: EN-US; mso-fareast-language: ES; mso-bidi-language: AR-SA">6-O-ascorbic acid alkanoates (ASCn, where n is the number of carbon atoms in the alkyl chain) behave as surfactants and form stable supramolecular assemblies in water, depending on chemical structure, concentration and temperature. In concentrated water dispersions, ASCn form liquid crystalline structures (?coagels?), below the critical micellar temperature (CMT), with a typical Krafft phenomenon. Such semisolid systems incorporate and stabilize drugs like anthralin, which is insoluble and unstable in aqueous media. The rheological behavior of coagels obtained from aqueous ASC8, ASC10, ASC11, ASC12, ASC14 and ASC16 was evaluated and related to the coagel structure. For ASC8, ASC12, ASC14 and ASC16 compl