Effect of Ascorbic Acid based amphiphiles on human erythrocytes membrane

MARTA RASIA,; ISABEL SPENGLER, MARIA; SANTIAGO PALMA,; RUBEN MANZO,; DANIEL ALBERTO ALLEMANDI

Clinical Hemorreology And Microcirculation

IOS Press

Año: 2007 vol. 36 p. 133 - 133

1386-0291

p class="MsoTitle" style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: justify">6-O-alkyl ascorbic acid esters (ASCn) are amphiphilic molecules that behave as surfactants in aqueous solution. These compounds show physico-chemical and aggregation properties that depend on the alkyl chain length, pH and temperature. Since the OH group in position 3 has a pKa¡Ö4.2, these molecules behave as anionic single chain surfactants. The biocompatibility of these compounds was evaluated by determining their hemolytic activity. ASCn induce hemolyis of erythrocytes at concentration substantially higher than their critical micellar concentration (CMC). The hemolytic activity depends on concentration and incubation time. ASCn have a higher tendency for autoaggregation than for penetration into