Resumen:
miodarone aqueous systems at concentrations C 6 3 mg/mL were studied with different techniques (conductivity, solubility, ion-selective electrodes, pH, viscosity, polarizing microscopy, computational simulation, electron microscopy and fluorescence at various temperatures. The Krafft point (TK = 70.6 C) was determined. A partial phase diagram was plotted showing the critical micelle concentration (CMC) dependence on temperature, the solubility and a transition between a coacervate and an unstable gel below TK as a function of temperature. The nature of aggregates below TK at different concentrations was determined. Micellization is an entropy-driven process which is probably caused by a strong dehydration of the amiodarone backbone on micellization. CMC, micelle aggregation number and TK given in earlier literature were misinterpreted in the original articles and are re-interpreted in this work.