A ciprofloxacin extended release tablet based on swellable drug polyelectrolyte matrices (SDPM).

MARIA BERMUDEZ, JOSE; JIMENEZ KAIRUZ, ALVARO; OLIVERA, MARIA EUGENIA; DANIEL ALBERTO ALLEMANDI; RUBEN MANZO,

AAPS PHARMSCITECH

American Association Pharmaceutical Scientist

Lugar: New York; Año: 2008 vol. 9 p. 924 - 924

1522-1059

span lang="en" style="font-family: ArialMT;">The aim of this work was the development of extended release tablets of 500 mg ofciprofloxacin based on swellable drug polyelectrolyte matrices (SDPM). A set of complexes of carbomer, ciprofloxacin and sodium, (CB?Cip)50Nax, having a molar ratio Cip/CB acid groups of 0.5 and variable proportions of Na+ was used to prepare SDPM. Characterization of complexes by FT-IR, powder X-ray diffraction and thermal analysis revealed that Cip, in its protonated form, is ionically bonded to the functional groups of CB. Rates of fluid uptake of (CB?Cip)50Nax matrices as well as Cip release in simulated gastric fluid were modulated by changes in the proportion of Na+ incorporated in the complexes. A direct correlation between fluid uptake and delivery rate was observed along the series of matrices. Release rates were modulated from 1.4 mg/min to 25 mg/min in going from (CB?Cip)50Na10 to (CB?Cip)50Na14. The analysis of kinetic data suggest that rates