Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan.

JUAN MANUEL LLABOT; HESHAM SALMAN; GIOCONDA MILLOTTI; ANDREAS BERNKOP-SCHNÜRCH; DANIEL ALLEMANDI; JUAN MANUEL IRACHE

TAYLOR & FRANCIS LTD

Año: 2011 vol. 28 p. 455 - 455

he aim of this study was to develop and characterize the bioadhesive properties of poly(anhydride) nanoparticles coated with two types of low-molecular weight chitosan (CH20 of 20 kDa or CH50 of 50 kDa) or their thiolated conjugates. Nanoparticles were prepared by a solvent displacement method and characterized by measuring the size, zeta potential, morphology and composition. For bioadhesion studies, nanoparticles were fluorescently labelled with rhodamine B isothiocyanate. In all cases, coated nanoparticles showed a slightly higher size and lower negative zeta potential than uncoated nanoparticles. Nanoparticles coated with CH20 showed a higher adhesive capacity than uncoated nanoparticles. On the contrary, when nanoparticles were coated with CH50, the resulting carriers displayed a decreased ability to develop adhesive interactions within the gut. Finally, the coating of nanoparticles with thiolated chitosan improved their adhesive abilities. Poly(anhydride) nanoparticl