ALLEMANDI DANIEL ALBERTO
Artículos
Título:
Albendazole nanocrystals with improved pharmacokinetic performance in mice
Autor/es:
PAREDES, ALEJANDRO J; BRUNI, SERGIO SÁNCHEZ; ALLEMANDI, DANIEL; LANUSSE, CARLOS; PALMA, SANTIAGO D
Revista:
Therapeutic Delivery
Editorial:
Future Science Group
Referencias:
Lugar: London; Año: 2018 vol. 9 p. 89 - 89
ISSN:
2041-5990
Resumen:
lbendazole (ABZ) is a broad-spectrum antiparasitic agent with poor aqueous solubility, which leads to poor/erratic bioavailability and therapeutic failures. Here, we aimed to produce a novel formulation of ABZ nanocrystals (ABZNC) and assess its pharmacokinetic performance in mice. Results/methodology:ABZNC were prepared by high-pressure homogenization and spray-drying processes. Redispersion capacity and solid yield were measured in order to obtain an optimized product. The final particle size was 415.69±7.40 nm and the solid yield was 72.32%. The pharmacokinetic parameters obtained in a mice model for ABZNC were enhanced (p < 0.05) with respect to the control formulation. Conclusion: ABZNCwith improved pharmacokinetic behavior were produced by a simple, inexpensive and potentially scalable methodology.
