Self-dispersible nanocrystals of azoxystrobin and cyproconazole with increased efficacy against soilborne fungal pathogens isolated from peanut crops

CAMILETTI, BORIS X.; CAMACHO, NAHUEL M.; PAREDES, ALEJANDRO J.; ALLEMANDI, DANIEL A.; PALMA, SANTIAGO D.; GROSSO, NELSON R.

POWDER TECHNOLOGY

ELSEVIER SCIENCE SA

Año: 2020 vol. 372 p. 455 - 455

0032-5910

elf-dispersible nanocrystals of azoxystrobin and cyproconazole were obtained by combining wet bead milling and spray-drying. Nanocrystals formulations were characterized and evaluated by their antifungal activity against S. minor and S. rolfsii. The mean particle sizes of azoxystrobin and cyproconazole nanosuspensions were 172.78 and 277.37 nm. Milling rotational frequency and milling time were the most significant process parameters. The contents of azoxystrobin and cyproconazole in their solid formulations were 45.3 and 43.3% w/w.Spray-dryingincreasedtheparticlesizeoffungicidenanocrystals(azoxystrobin,323.68nm;cyproconazole, 456.53 nm). The method of production showed a solid yield of 44.5% for azoxystrobin and 34.5% for cyproconazole. Themethodologyusedinthisstudydoesnotaffectthecrystallinityoffungicides.Nanocrystalformulations remarkably improved the performance of fungicides and have no negative consequences on peanut growth. The use of self-dispersible nanocrystals is presented