ALLEMANDI DANIEL ALBERTO
Artículos
Título:
Latanoprost-loaded phytantriol cubosomes for the treatment of glaucoma
Autor/es:
BESSONE, CAROLINA DEL VALLE; AKHLAGHI, SEYEDEH PARINAZ; TÁRTARA, LUIS IGNACIO; QUINTEROS, DANIELA ALEJANDRA; LOH, WATSON; ALLEMANDI, DANIEL ALBERTO
Revista:
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2021 vol. 160
ISSN:
0928-0987
Resumen:
laucoma is a degenerative optic neuropathy characterized by increased intraocular pressure that if untreated can result in blindness. Ophthalmological drug therapy is a challenge of great clinical importance due to the diversity of ocular biological barriers which commonly causes limited or no effectiveness for drugs delivered through the eye. In this work, we proposed the development of nanosized cubic liquid crystals (cubosomes) as a new drug carrier system for latanoprost, an anti-glaucoma drug. Latanoprost-loaded phytantriol cubosomes (CubLnp) were prepared using a top-down method. Latanoprost concentration in the formulations ranged from 0.00125% to 0.02% w/v. All cubosomes displayed an average size around 200 nm, a low polydispersity index of 0.1 and zeta potential values around ?25 mV, with an encapsulation efficiency of about 90%. Structural studies revealed that cubosomes displayed a double-diamond surface, Pn3m cubic-phase structure, and was not affected by drug loading. Cal