Phase behavior of ascorbyl palmitate in PEG400 solution

L. BENEDINI; P. MESINA; P. SCHULZ; D. ALLEMANDI; S. PALMA

Córdoba

Congreso; Primera Reunion Internacional de Ciencias Farmacéuticas – RICiFa; 2010

Grupo Farmacotecnia. FCQ-UNC

The phase diagram of the system Asc16-solution (25% (w/w) PEG400 in 75% (w/w) has been done. The PEG 400 added to solution reduces the transition temperatures because it decreases the compactness of the lamellar structure. The degree of diminution of the transition temperatures produced by this proportion of PEG400 with regard to Asc16-water system was not singinficant. However, to work with LC at room temperature, we have to achieve stabilization of this mesophase. Stable liquid crystals phase is the future of the development of Asc16 applications.