Evaluation of rapidly disintegrating tablets based on solid dispersions.

CASTRO S.; ALLEMANDI D.; PALMA S.

Córdoba

Congreso; Primera Reunion Internacional de Ciencias Farmacéuticas – RICiFa; 2010

Solid dispersions (SDs) have been proposed as an alternative to improve the dissolution rate of low solubility drugs. In previous studies, SDs containing albendazole (ABZ) and poloxamer188 (P188) were formulated. The dissolution profiles indicated that ABZ incorporated in SDs (as multiparticles) was rapidly released compared with free ABZ. The aim of the present study was to develop and evaluate rapidly disintegrating tablets (RDT) containing ABZ – P188 DSs.