Enhance of trascorneal permeation using novel eudragit-flurbiprofen complexes

QUINTEROS D.; TARTARA I.; PALMA S.; ALLEMANDI D.

Córdoba

Congreso; Primera Reunion Internacional de Ciencias Farmacéuticas – RICiFa; 2010

Grupo Farmacotecnia. FCQ-UNC

This work was carried out in the framework of a project concerning the development of new ophthalmic drug delivery systems. It is based on the properties of Polymethacrylates (Eudragit®, Eu)-drug complexes, which are able to increase the aqueous compatibility of low solubility drug. The aim of the work was the assessment of physico-chemical, pharmaceutical and biopharmaceutical properties of these complexes. Flurbiprofeno (Fl) was selected as active and Eudragit®-Fl complexes were formulated in aqueous solution, which was subjected to transcorneal permeation assays as well as the evaluation of its potential ocular irritation in rabbits.