Inmunoadyuvant effect of oligodeoxynucleotids with cpg motifs (CpG-ODN) loaded in nanostructureted systems (coageles).

SANCHEZ VALLECILLO M.; ULLIO GAMBOA G.; PALMA S.; ALLEMANDI D.; MORÓN G.; PISTORESI M.; MALETTO B.

Córdoba

Congreso; Primera Reunion Internacional de Ciencias Farmacéuticas – RICiFa; 2010

Grupo Farmacotecnia. FCQ-UNC

CpG-ODN has shown very promising inmunoadyuvant activity. Despite successes demonstrated in early clinical trials, the clinical use of free CpG-ODN remains still uncertain because some troubles (enzymatic degradation, unfavorable pharmacokinetics, a lack of specificity for target cells and poor cellular uptake). In order to improve the biodisponibility of CpG-ODN, we used CpG-ODN formulated in nanostructures (coagels) of 6-O- ascorbyl palmitate (Coa-ASC16), wich has the ability to form supramolecular aggregate that are produced by phase cooling below a critical micellar temperature.