Tablets formulation of solidago chilensis by direct compression using a novel dry plant extract

BUCCIARELLI A.; GALLO L.; ALLEMANDI D.; SKLIAR M.

Córdoba

Congreso; Primera Reunion Internacional de Ciencias Farmacéuticas – RICiFa; 2010

Grupo Farmacotecnia. FCQ-UNC

Folk medicine has employed plant extracts since ancient times to treat gastrointestinal diseases. Solidago chilensis Meyen (Asteraceae) is a native species from South America commonly known as “vara dorada”, widely used in the popular medicine of different countries (1). Recently we reported the antiulcerogenic activity of the aqueous extract of the plant in mice subjected to an experimental model of ethanol-induced gastric lesions (2). The active component for the formulation of a phytomedicine in the form of tablets is usually a dry plant extract. However many dry plant extracts, including S. chilensis, have poor flow properties for direct compression (DC). In the present work the development of solid pharmaceuticaldosage formulations using a novel dry plant extract (NDPE) of Solidago chilensis is proposed for the first time.