EFFECTIVENESS OF ENHANCERS? COMBINATION ON TRANSDERMAL PERMEATION OF PROBENECID

LHEZ L; ALLEMANDI DA; PAPPANO NB; DEBATTISTA NB

Rosario

Congreso; Congreso de la Sociedad Argentina de Farmacología Experimental. SAFE 2009; 2009

The pharmaceutical design is a very complex field due to the existence of multiple forms of administration. The oral route presents some disadvantages such as gastric irritation, exposition of the drug to extreme pH and degradation by hepatic first pass. A non-invasive alternative to avoid these effects are the transdermal formulations, which present the advantage to release the drug in constant and prolonged way. Nevertheless the transdermal drug administration itself is limited by the characteristics of the skin, which offers a remarkable resistance to the penetration of the active principles. Therefore, it is necessary to include in the formulations chemical compounds that, by different mechanisms, facilitate the penetration of the drug. In this study, using Franz diffusion cells, in vitro transdermal permeation of probenecid (uricosuric drug) in solid vaseline through dermatomized pig skin was assayed.