INTERPOLYELECTROLITE-DRUG COMPLEX NANOPARTICLES AS BASIC DRUGS CARRIER

PALENA M.; ALLEMANDI D.; MANZO R.; JIMENEZ-KAIRUZ A.

Rosario

Congreso; Congreso de la Sociedad Argentina de Farmacología Experimental. SAFE 2009; 2009

The aim of this project was to obtain polyelectrolyte/drug complex nanoparticles (NP). With this purpose two polymethacrylates, one anionic (eudragit L100 (EuL) and other cationic (eudragit E100 (EuE)) were selected to prepare ionic complexes with the model drugs (D), atenolol and propranolol. Aqueous dispersions of the obtained particles were subjected to physicochemical characterization and in vitro release studies.