Testing of an autogelling elastin like recombinamer- for ophthalmic applications.

ALICIA FERNÁNDEZ-COLINO, ; DANIELA QUINTEROS, ; SANTIAGO DE PALMA, ; DANIEL ALLEMANDI, ; JOSÉ C. RODRÍGUEZ-CABELLO, ; FRANCISCO J ARIAS.

Genova

Congreso; Tissue Engineering and Regenerative Medicine International Society ? EU Meeting -2014 Genova, Ialy; 2014

Tissue Engineering and Regenerative Medicine International Society

An alternative to increase the residence time of formulations in the area of application is the use of bioadhesive systems. Taking this into account, we propose the incorporation of an autogelling elastin-like recombinarmer (ELR) 1 in the development of an ophthalmic formulation. Our hypothesis is that due to the thermo-sensitive behavior of this polymer, the formulation could be administered topically as drops, and once sensing the temperature of the eye, suffer a shift to a gel system, , which could help to prolong the permanence of the formulation in the eye, and therefore, could facilitate the passage of the drug.