Solid dispersions. A tool to improve the dissolution rate of oxfendazole.

MARINA SILVANA ARDUSSO, ; DANIEL ALLEMANDI, ; SERGIO SÁNCHEZ BRUNI , ; SANTIAGO PALMA.

Mar del Plata

Congreso; XLVIII Reunión Anual de la Sociedad Argentina de Farmacología Experimental (SAFE); 2016

SAFE

+ntroduction 2arasitism is a disease that may affect men and pets as Yell. Treating this disease, Anthelminticsbenzimidazoles have achieved a therapeutic significance due to theircharacteristics of broad spectrum, loY toxicity and loY cost. The formulation, bioavailability and efficacy of anthelminticsare limited by the loY gastrointestinal absorption and lacM of aqueous solubility. To confront this, several technological methods have been reported for the improvement of drug solubility and dissolution rate. Such an approach, with significant advantages, is the formulation of hydrophobic drugs in high energy amorphous forms, such as solid dispersions S&s. 1ur hypothesis is to increase the rate of dissolution oxfendazole 1F< incorporating it in S&s as a strategy to improve bioavailability. 1$,ECT+8E 2repare and evaluate physi-cochemical and biopharmaceutical properties of S&s using poloxamer as carrier of methods were prepared by melting of 1 and 2. The systems were characterized by diffraction, Scanning Electron microscopy SEM, solubility studies, and dissolution tests. Results interactions between the components of were observed in diffractograms. The SEM of observed irregular particles where it is not possible to differentiate the 1 from 2. While in physical mixture, the 1 can be seen spread over the carrier surface. The solubility indicates that if 2:/ presence is up tov/v then 1F< solubility in is not altered. In addition, and mg 1F< S&s dissolution profiles at time min shoYed an increasedrate of . and . respectively, compared to the same dose of 1F<. 9hereas applying the F difference factor to the corresponding and mg S&s profiles, it determined a curve overlapping. This increase in dissolution rate may be due to the presence of 2:/ that improves the particles Yettability. Conclusions +n every evaluated dose, a remarMable increase in 1F< dissolution rate in S&s is achieved in comparison to 1F<.