Resumen:
p style="TEXT-ALIGN: justify; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt; mso-layout-grid-align: none" class="MsoNormal">The complex formation between three structurally related sulfonamides (sulfadiazine (SDZ), sulfamerazine (SMR), and sulfamethazine (SMT)) and b-cyclodextrin (B-CD) was studied, by exploring its structure affinity relationship. In all the cases, 1:1 stoichiometries were determined with different relative affinities found by phase solubility (SDZ:B-CD>SMR:B-CD>SMT:B-CD) and nuclear magnetic resonance (NMR) (SMT:B-CD>SMR:B-CD>SDZ:B-CD) studies. The spatial configurations determined by NMR were in agreement with those obtained by molecular modeling, showing that SDZ included its aniline ring into B-CD, while SMR and SMT included the substituted pyrimidine ring. Energetic analyses demonstrated that hydrophobicity is the