Interaction of sulfadiazine with cyclodextrins in aqueous solution and solid state

DELRIVO A.; ZOPPI A.; LONGHI M. R.

ELSEVIER SCI LTD

Año: 2012 vol. 87 p. 1980 - 1980

font size="1" face="GulliverRM"> The main objective of this work was to increase the solubility of sulfadiazine by formation of inclusion complexes with B-cyclodextrin, and methyl-B-cyclodextrin. The apparent stability constants have been determined by phase solubility studies in water and buffer solutions of pH values of 2 and 8. The stoichiometry of all complexes was found to be 1:1 but different relative affinities were found for each cyclodextrin. It was possible to obtain a greater overall solubility by using a combined approach of pH adjustment and complexation with cyclodextrins. Guest-host interactions have been investigated using nuclear magnetic resonance. Complexes were prepared in solid state by different methods and were characterized using differential scanning calorimetry, thermogravimetric analysis, Fourier-transform infrared spectroscopy, X-ray diffractometry and scanning electron microscopy. The dissolution rate of th