Ternary complexation of benzoic acid with β-cyclodextrin and aminoacids. Experimental and theoretical studies

GARCÍA MÉNDEZ S.; OTERO ESPINAR F.J.; LUZARDO ALVAREZ A.; LONGHI M. R.; QUEVEDO M.A.; ZOPPI A.

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY

SPRINGER

Lugar: Berlin; Año: 2016 vol. 85 p. 33 - 33

0923-0750

#946;-Cyclodextrin (β-CD) is a well-known host molecule used to prepare inclusion complexes. Considering that the three dimensional array of these complexes depends on the inclusion mode of the guest molecule within the β-CD cavity, the development of methods to elucidate their structure is highly desired. The main objective of this work aimed to shed light on the structural and energetic features related to the effect of aminoacids (AA: glycine, valine, isoleucine, arginine and glutamic acid) as third components on the complexation of benzoic acid (BA) with β-CD. In addition, hippuric acid (HA), a structure resembling a BA-glycine conjugate, was included as a model molecule to compare the effect of glycine present as a chemical moiety covalently linked to the guest molecule. Phase solubility analyses were performed to determine the relative binding affinities for binary (BA:β-CD and HA:βCD) and ternary (BA:β-CD:AA) complexes, obtaining the following resu