Studies of pilocarpine:carbomer intermolecular interactions

ZOPPI A.; GARRO LINCK Y.; MONTI G.A.; GENOVESE D.; JIMÉNEZ KAIRUZ A.F.; MANZO R. H.; LONGHI M. R.

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2012 vol. 427 p. 252 - 252

font size="3" face="TimesNewRomanPSMT"> The interactions between pilocarpine (PIL) and the anionic polyelectrolyte carbomer (CBR) were investigated. The effects of the chemical interactions on the chemical stability of the drug also were evaluated. The binary system was characterized by nuclear magnetic resonance techniques, fourier-transform infrared spectroscopy, X-ray powder diffraction, scanning electron microscopy and thermal analysis. The experiments showed that the complex, prepared by freeze-drying, is a solid amorphous form different from its precursors, thereby offering an interesting alternative for the preparation of extended release matrices. The solution stability of PIL was studied at pH 7 and 8, at 70 ºC. The PIL solution stability was evaluated al