Studies on trimethoprim:hydroxypropyl-B-cyclodextrin: aggregate and complex formation

CLAUDIA GARNERO; ARIANA ZOPPI; DIEGO GENOVESE; MARCELA R. LONGHI

ELSEVIER SCI LTD

Año: 2010 vol. 345 p. 2550 - 2550

p style="TEXT-ALIGN: justify; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt; mso-layout-grid-align: none" class="MsoNormal">The present study is focused on the characterization of the interaction between trimethoprim, a dihydropteroate synthesase inhibitor, and hydroxypropyl-B-cyclodextrin (HP-B-CD) in aqueous solution and solid state. The freeze-drying method was used to prepare solid complexes, while simple blending was employed to obtain physical mixtures. The phase solubility was AN type, and demonstrated that trimethoprim solubility was significantly increased upon complexation with HP-B-CD. Conductivity experiments showed the presence of aggregates that explains the type profile for the solubility isotherm.