Lipophilicity of Novel 5-Carbonates of Lamivudine With Antirretroviral Activity. Correlation Between Different Methods.

SOLEDAD RAVETTI, MARÍA SOLEDAD GUALDESI, MARGARITA CRISTINA BRIÑÓN

TAYLOR & FRANCIS INC

Año: 2008 vol. 31 p. 1014 - 1014

his study reports on the lipophilicity of novel 5-carbonates of lamivudine with anti-HIV activity. Reversed-phase thin layer chromatography (RP-TLC), reversed-phase high performance liquid chromatography (RP-HPLC), conventional shake-flask (log Poct), and the theoretical CLOGP methods were used, in order to establish if the linear relationships between the conventional and chromatographic methods permit an extrapolation procedure. The nature of the organic modifiers used in the chromatographic techniques did not substantially affect the measurement of lipophilicity, since a good correlation between experimental log Poct and extrapolated RP-TLC and RP-HPLC values (RMw and log kw, respectively) supported the validity of the extrapolation technique.