Permeation in Artificial Membrane of Allopurinol Derivatives with Potential Anti-T Cruzi Activity

GUALDESI, MARÍA S., LONGHI, MARCELA R., GRANERO, GLADYS, RAVIOLO, MÓNICA, A.

International Journal Of Pharmaceutical Sciences And Research

Institute of Pharmacy, Bundelkhand University Jhansi (U.P.), India

Año: 2014

!--[if gte mso 9]> 800x600 Chagas disease is caused by Trypanosoma cruzi (T. cruzi), and is a major healthproblem in Central and South America that affects nearly 8-10 million people. Allopurinol(Allop) acts inhibiting the parasite, but it presents unfavorablephysicochemical properties causing versatile responses in patients with Chagas. In an attempt