Synthesis, Physicochemical Properties and Biological Activity Against Trypanosoma Cruzi Of Allopurinol Derivatives

RAVIOLO, MÓNICA A.; SOLANA, MARÍA E.; NOVOA, MARÍA M.; GUALDESI, MARÍA S.; ALBA-SOTO. CATALINA D.; BRIÑÓN. MARGARITA C.

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

Lugar: Paris; Año: 2013 vol. 69 p. 455 - 455

hagas disease is caused by Trypanosoma cruzi (T. cruzi) leading to a huge number of infections and deaths per year, because in addition to many sufferers only having limited access to health services only an inefficient chemotherapy is available using drugs such as benznidazole and nifurtimox. Here, C6-alkyl(2aec) and N1-acyl (3aec) derivatives of Allopurinol (Allop, compound with activity against T. cruzi) were synthesized in good yields and their structures were unambiguously characterized. Only 2a, 2b and 3c showed inhibitory activity against the proliferative stages of the parasite when tested at 1 mg mL1 with the 3c derivative exhibiting an IC50 value similar to that of Allop and not being toxic for mammalian cells. Relevant pharmaceutical physicochemical properties (pKa, stability, solubility, lipophilicity) were also determined as well by using Lipinski?s rule, polar surface area and molecular rigidity. Taken together, the results demonstrated that the studied derivatives had o