New poly(acrylamide) nanoparticles in the development of third generation photosensitizers

GUALDESI, M.S.; VARA, J.; AIASSA, V.; ALVAREZ IGARZABAL, C.I.; ORTIZ, C.S.

DYES AND PIGMENTS

ELSEVIER SCI LTD

Año: 2021 vol. 184

0143-7208

here are promising data on the use of poly(acrylamide) nanoparticles (PAA-NPs) in the development of third generation photosensitizers for application in antimicrobial photodynamic therapy. These nanoparticle delivery systems are suitable for biological applications and have potential for drug delivery due to their biocompatibility, chemical flexibility, easy preparation and low cost. The objective of this work was to obtain new PAA-NPs for the vehiculization of the monobrominated de-rivatives of Azure B (AzBBr) and Neutral Red (NRBr). These two dyes were found to have promising properties as photosensitizers. However, the use of nanotechnology was required to overcome difficulties in solubility, ag-gregation and stability in order to optimize their photodynamic efficiency. The combination of different monomers and crosslinkers allowed us to develop two new PAA-NPs. These systems were loaded with AzBBr and NRBr and characterized according to their morphology, size, polydispersity inde