Design of polymeric carriers to enhance antimicrobial photodynamic inactivation

VARA, JIMENA; GUALDESI, MARÍA S.; FERNÁNDEZ, MARIANA A.; ORTIZ, CRISTINA S.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

EDITIONS SANTE

Año: 2024 vol. 94

1773-2247

ixed polymeric micelles are a promising tool for the design of nanocarriers with pharmaceutical properties. These micellar systems allow reversing numerous properties of lipophilic drugs. Particularly, when applied to transport photosensitizers (PSs), they give rise to a wide variety of nanophotosensitizers (nPSs). These compounds are used to inactivate numerous bacteria resistant to conventional antibiotics. This research proposes the development of new mixed micelles, with better properties than simple micelles, for the trapping of Neutral Red (NR) and its monobrominated derivative (NRBr). Based on the combination of Pluronic P-123 with Pluronic F- 108, Pluronic L-61 and Tween 80, 15 binary micellar systems were obtained. These mixed micelles presented a single population of homogeneous particles, with a diameter less than 70 nm. Moreover, several mixed micelles show smaller CMC than the simple system. These properties are predictors of high micellar stability and good anti-dilution