Permeation in Artificial Membrane of Allopurinol Deruvatives With Potential Anti-T Cruzi Activity.

GUALDESI, MARÍA S., LONGHI, MARCELA R., GRANERO, GLADYS, RAVIOLO, MÓNICA, A.

Congreso; 3° Reunión Internacional de Ciencias Farmacéuticas (RICiFa).; 2014

Facultad de Ciencias Químicas. Universidad Nacional de Córdoba.

Chagas disease is caused by Trypanosoma cruzi (T. cruzi), and is a major health problem in Central and South America that affects nearly 8-10 million people. Allopurinol (Allop) acts inhibiting the parasite, but it presents unfavorable physicochemical properties causing versatile responses in patients with Chagas. In an attempt to improve its performance, we have developed twelve derivatives of Allop by chemical modification, resulting in active anti-T cruzi agents per se or prodrugs compounds.1 The present study deals with the permeability of Allop and its derivatives (like an additional study in drug development) by using artificial membranes as an in vitro technique.