Metal-Free Intramolecular Ketone Arylation An SRN1 Approach Towards Tetracyclic Indole and 7-Aza Indole Motifs

MAURICE MEDEBIELLE; CHERIF ADOUAMA; WALTER D. GUERRA; MARÍA E. BUDÉN; G. GASNIER; G. FOURNET; B. JOSEPH; MARCELO PUIATTI; JAVIER I. BARDAGÍ; SILVIA M. BAROLO; ROBERTO A. ROSSI

Cocón

Congreso; 14º Conferencia Latinoamericana de Físico-química Orgánica (CLAFQO); 2017

CLAFQO

In connection to our research programs dedicated to the development of synthetic useful electron-transfer methodologies and the discovery of potent bioactive substances, we will disclose a new, efficient and non-contaminant methodology to prepare these motifs. The approach is based on a metal-free SRN1 intramolecular ketone arylation, which do not rely on the use of palladium in combination with toxic or expensive/sophisticated ligands, or other stoichiometric tin and transition metals reagents.