Early Onset and Temporo-Spatial Switch of Melanopsin Isoforms Expression in The Developing Chicken Retina

VERRA DM; CONTIN MA; HICKS D; GUIDO ME

ASSOC RESEARCH VISION OPHTHALMOLOGY INC

Año: 2011 vol. 52 p. 5111 - 5111

p style="TEXT-ALIGN: justify; LINE-HEIGHT: 200%; MARGIN: 0cm 0cm 0pt; mso-layout-grid-align: none" class="MsoNormal">Purpose:  Retinal ganglion cells (RGCs) expressing the photopigment melanopsin (Opn4) display intrinsic photosensitivity. Here, we investigated the presence of non-visual phototransduction cascade components in the developing chicken retina and primary RGCs cultures, focusing on the two Opn4 genes, the Xenopus (Opn4x) and the mammalian (Opn4m) orthologs.