The mouse liver displays daily rhythms in the metabolism of Phospholipids? .

GORNE LD; ACOSTA-RODRIGUEZ VA; PASQUARE S; SALVADOR G; GIUSTO NM; GUIDO ME

TAYLOR & FRANCIS INC

Lugar: Londres; Año: 2015 vol. 32 p. 11 - 11

p style="TEXT-ALIGN: justify; LINE-HEIGHT: 200%; MARGIN: 0cm 0cm 0pt; tab-stops: center 220.95pt left 12.0cm right 441.9pt" class="MsoNormal">The circadian system involves central and peripheral oscillators regulating temporally biochemical processes including lipid metabolism; their disruption leads to severe metabolic diseases (obesity, diabetes, etc). Here, we investigated the temporal regulation of glycerophospholipid (GPL) synthesis in mouse liver, a well-known peripheral oscillator. Mice were synchronized to a 12:12 h light dark (LD) cycle and then released to constant darkness with food ad libitum. Livers collected at different times exhibited a daily rhythmicity in some individual GPL content with highest levels during the subjective day. The activity of GPL-synthesizing/remodeling enzymes: phosphatidate phosphohydrolase 1 (PAP-1/Lipin) and lysophospholipid acyltransferases (LPLATs) also displayed significant variations, with higher levels during