EXPRESSION OF NOVEL OPSINS AND INTRINSIC LIGHT RESPONSES IN THE MAMMALIAN RETINAL GANGLION CELL LINE RGC-5. PRESENCE OF OPN5 IN THE RAT RETINA.

NIETO PS; VALDEZ DJ; ACOSTA-RODRÍGUEZ VICTORIA A.; GUIDO ME

PUBLIC LIBRARY SCIENCE

Año: 2011 vol. 6 p. 1 - 1

p style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt" class="MsoNormal" align="center">Abstract According to the current knowledge, the vertebrate retina contains three classes of photoreceptor cells: cones and rods responsible for vision, and intrinsically photoresponsive retinal ganglion cells (RGCs) involved in diverse non-visual functions such as photic entrainment of daily rhythms and pupillary light responses. In this paper we investigated the potential capability of the rat RGC line, RGC-5, as intrinsic photoreceptors by assessing the presence of visual and non-visual opsins as well as the responses to brief light pulses on the expression of the immediate-early gene protein c-Fos and intracellular C