?Ï Echinococcus granulosus glycoconjugates induce peritoneal B cell differentiation into antibody secreting cells and cytokine production.

MOURGLIA ETTLIN GUSTAVO; AMEZCUA VESELY MARIA CAROLINA; FRAGA REGINA; MERINO MARIA CECILIA; GRUPPI ADRIANA; DEMATTEIS SYLVIA

WILEY-BLACKWELL PUBLISHING, INC

Año: 2011

font face="Helvetica"> Helminth parasite infections are associated with predominant Th2-type cytokine responses, and parasite glycoconjugates have been recognized as partially responsible for such immune bias. It has been proved that Echinococcus granulosus evokes a Th2-type cytokine pattern characterized by a high production of IL-4, IL-5, IL-6 and IL-10, and no or mild IFN-£^ levels in animal models and in cystic echinococcosis patients, respectively. Here we show that E4+ (a glycoconjugate-enriched fraction from E. granulosus