"B-Cell Response during Protozoan Parasite Infections,"

AMEZCUA VESELY MARIA CAROLINA; BERMEJO DANIELA ANDREA; MONTES CAROLINA LUCIA; ACOSTA RODRIGUEZ, EVA VIRGINIA; GRUPPI ADRIANA

Journal of Parasitology Research

Hindawi

Lugar: Nueva York; Año: 2012 vol. 2012 p. 1 - 1

2090-0023

font size="1" face="Minion-Regular"> In this review, we discuss how protozoan parasites alter immature and mature B cell compartment. B1 and marginal zone (MZ) B cells, considered innate like B cells, are activated during protozoan parasite infections, and they generate short lived plasma cells providing a prompt antibody source. In addition, protozoan infections induce massive B cell response with polyclonal activation that leads to hypergammaglobulnemia with serum antibodies specific for the parasites and self and/or non related antigens. To protect themselves, the parasites have evolved unique ways to evade B cell immune responses inducing apoptosis of MZ and conventional mature B cells. As a consequence of the parasite induced-apoptosis, the early IgM response and an already establish humoral immunity ar