Peritoneum from Trypanosoma cruzi infected mice is a homing site of Syndecan-1neg plasma cells which mainly provide non-parasite specific antibodies

MC MERINO, CL MONTES, EV ACOSTA-RODRIGUEZ, DA BERMEJO, MC AMEZCUA VESELY Y A GRUPPI

OXFORD UNIV PRESS

Año: 2010 p. 399 - 399

font face="AdvPSHEL-B" size="1"> Humoral immunity during experimental Chagas disease has been considered a double-edge sword, critical to control Trypanosoma cruzi spreading but also associated to tissue damage. Peritoneal B-1 cells have been linked to the pathogenesis of Chagas disease; however, they may also help to control the infection by providing a fast wave of antibodies. In the present work, we determined that peritoneal B-cell response to T. cruzi is characterized by a marked reduction of CD19