Trypanosoma cruzi infection induces a massive extrafollicular and follicular splenic B cell response which is a high source of non-parasite specific antibodies.

BERMEJO, DANIELA; AMEZCUA VESELY, MARIA; KAHN, MAHMOOD; ACOSTA-RODRÍGUEZ, EVA; MONTES, CAROLINA; MERINO, MARIA; TOELLNER, K M; MOHR, ELODIE; TAYLOR, DALE; CUNNINGHAM, A; GRUPPI, ADRIANA

WILEY-BLACKWELL PUBLISHING, INC

Año: 2011 p. 123 - 123

font face="AdvMINION-SB" size="2"> Acute infection with Trypanosoma cruzi, the aetiological agent of Chagas’ disease, results in parasitaemia and polyclonal lymphocyte activation. It has been reported that polyclonal B-cell activation is associated with hypergammaglobulinaemia and delayed parasite-specific antibody response. In the present study we analysed the development of a B-cell response within the different microenvironments of the spleen during acute T. cruzi disease, results in parasitaemia and polyclonal lymphocyte activation. It