Long-lived TRM cells derive from effector TH17 cells and are essential for an immediate response against antibiotic resistant bacterial infection

FLAVELL, RICHARD A.

CELL

CELL PRESS

Lugar: United States; Año: 2019

0092-8674

ong-lived TRM cells derive from effector TH17 cells and are essential for animmediate response against antibiotic resistant bacterial infection.Mucosal barrier surfaces serve as the critical first line of defense separating ourbodies from the plethora of pathogenic microorganisms that inhabit ourenvironment. Adaptive immunity provides life-long protection through thegeneration of a central and effector memory T-cell pool, memory B cells and therecently described population of tissue resident memory cells (TRM). The cellularorigin of TRM CD4 cells is unknown and the contribution of this CD4 memorypopulation in host defense still remains elusive. By using IL-17A tracking-fatemousemodels we found that CD4 TRM cells derive from IL-17A producing effector(TH17) cells following primary immunization. Here we show that neither antibodiesnor circulatory memory T cells are sufficient for a rapid host defense. Usingparabiosis and depletion studies, we demonstrated that in-situ resting CD4 memorye